NIH Proteomics Interest Group

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ProtIG is an NIH Special Interest Group (SIG) that organizes seminars and workshops in relevant areas of proteomics, including talks on separation and protein identification methods, determination of post-translational modifications, protein-protein interactions, and bioinformatics and data management. A monthly seminar series is usually held at 11am on the first Wednesday of each month (always check the Mtgs/Seminars button on this page for these and other PROTIG announced meetings). To receive email announcements of ProtIG events, join the listserv (Join the SIG button on this page)

October ProtIG Seminar
Please note change in time and location
October 4th, 2017
11:00 am - 12:00pm
Building 50, NIH Campus
Room 1227/1233 (Front Lobby Conference Room)
Benjamin Garcia, Ph.D
Presidential Professor of Biochemistry and Biophysics,
Epigenetics Program
Department of Biochemistry and Biophysics
University of Pennsylvania

"Quantitative Proteomics for Understanding Modified Proteins and Proteomes"

Mass spectrometry has become a powerful tool for characterization of thousands of proteins from any cellular source. Here in this presentation, I will highlight advances in mass spectrometry based methodology to detect post-translational modifications on histone proteins involved in epigenetic regulation of gene expression, dynamics of global protein modifications and to also identify RNA-protein interaction domains. We will specifically describe high-throughput comparison of proteins from multiple cellular states (ii) mass spectrometry methods for quantitative tracking of combinatorial modifications (iii) monitoring in vivo post-translational modification dynamics, and (iv) instrumental methods to improve data acquisition. These studies in combination with biological experiments will help provide a systems biology outlook on gene expression that will lay down the basic scientific foundation to advance several applications, such as stem cell reprogramming and cancer progression.

Seminars will be webcast online at and available on the
Proteomics Interest Group website as an archived presentation unless otherwise noted.

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This site was updated on September 26th, 2017. Please contact Renee Olano at olanol(at) with questions or suggestions.