NIH Proteomics Interest Group

Link to Upcoming Meetings

Link to Meeting Archives

Link to Related Links

Link to NIH Labs

Link Fellows Forum Info

Link to Join SIG


ProtIG is an NIH Special Interest Group (SIG) that organizes seminars and workshops in relevant areas of proteomics, including talks on separation and protein identification methods, determination of post-translational modifications, protein-protein interactions, and bioinformatics and data management. A monthly seminar series is usually held at 12 pm on the Second Thursday of each month (always check the Mtgs/Seminars button on this page for these and other PROTIG announced meetings). To receive email announcements of ProtIG events, join the listserv (Join the SIG button on this page)

May ProtIG Seminar
Thursday, May 16th, 2024
1:00 pm - 2:00 pm ET
NIH Building 50
Room 1227/1233
Brian Searle, Ph.D.
Assistant Professor
Department of Biomedical Informatics
Ohio State University Medical Center

“Identifying novel pediatric pancreatitis biomarkers with urine proteomics”

Acute pancreatitis (AP) is an inflammatory disorder of the pancreas and is among the most common gastrointestinal disorders resulting in hospitalization worldwide. Diagnosis of AP remains challenging for two reasons: 1) current biomarkers (serum lipase and amylase) have poor specificity to pancreatic disease, and 2) the temporal nature of AP complicates point-of-care testing that requires blood-based biomarkers. In this work, we apply urine proteomics to study a discovery cohort containing 130 pediatric patients under 21 years old including a mixture of AP subjects, chronic pancreatitis (CP) subjects, extremity fracture pain controls, and healthy controls. We identified five robustly differential proteins that statistically segregated AP from other groups, including the previously known biomarker, pancreatic alpha-amylase (AMY2A). As part of this talk, we will also discuss modes of proteomics data acquisition and analysis that facilitate biomarker discovery and validation in complex and diverse cohorts. This work underlines the promising role of urinary markers in the diagnosis of AP and the potential f or non-invasive testing that can provide timely and accurate diagnosis.

This seminar will be videocast on

NIH Videocast

Please mute your microphone and use the "raising hand" option to indicate a question.

Seminars will be webcast online and available on the
Proteomics Interest Group website as an archived presentation unless otherwise noted.

NIH Special Interest Groups home page NIH Home Page

This site was updated on May 14th, 2024. Please contact Renee Olano at olanol(at) with questions or suggestions.