NIH Proteomics Interest Group

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ProtIG is an NIH Special Interest Group (SIG) that organizes seminars and workshops in relevant areas of proteomics, including talks on separation and protein identification methods, determination of post-translational modifications, protein-protein interactions, and bioinformatics and data management. A monthly seminar series is usually held at 10 am on the Second Thursday of each month (always check the Mtgs/Seminars button on this page for these and other PROTIG announced meetings). To receive email announcements of ProtIG events, join the listserv (Join the SIG button on this page)

January ProtIG Seminar
Thursday, January 9th, 2020
10:00 am - 11:00am
Building 50, NIH Campus
Room 1328/1334 (Rear Conference Room)
Jace Jones, Ph.D.
Assistant Professor
Associate Director of the Mass Spectrometry Center
Department of Pharmaceutical Sciences
School of Pharmacy, University of Maryland, Baltimore, MD



"Identification of Lipid Biomarkers in Traumatic Brain Injury via the Generation of Mass Spectrometry-based Multidimensional Data"

Lipids have significant potential to inform on disease and injury due to the pivotal role they play in many biological processes including cellular integrity and permeability, energy storage and metabolism, and signaling pathways. Heightened interest in the mechanism by which disruption of lipid metabolism and homeostasis contributes to a variety of human diseases and injuries (e.g., cancer, diabetes, neurodegenerative disorders, infectious diseases, and pulmonary conditions) has led to a substantial increase in lipidomic research. The field of lipidomics, broadly described as the comprehensive biochemical characterization of “all” lipids (referred to as the lipidome) within a cell, tissue, or organism presents a variety of analytical and data processing challenges. The analytical challenges result primarily from the dynamic range, vast structural diversity, and sheer number of biological lipids. For example, a single blood sample contains over 10,000 individual lipids covering a dynamic range of low picomolar to high micromolar concentrations. Here, I will present the rationale for integrating liquid chromatography and ion mobility separation in-line with high resolution, tandem mass spectrometry for identifying lipid biomarkers in a traumatic brain injury model. The combined effort of aligning multidimensional mass spectrometry data with a well-defined traumatic brain injury model lays the foundation for gaining mechanistic insight into neuronal cell death following brain injury.






Seminars will be webcast online at http://videocast.nih.gov and available on the
Proteomics Interest Group website http://proteome.nih.gov as an archived presentation unless otherwise noted.



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This site was updated on December 30th. Please contact Renee Olano at olanol(at)mail.nih.gov with questions or suggestions.