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| ProtIG is an NIH Special Interest Group (SIG) that organizes seminars and workshops in relevant areas of proteomics, including talks on separation and protein identification methods, determination of post-translational modifications, protein-protein interactions, and bioinformatics and data management. A monthly seminar series is usually held at 12 pm on the Second Tuesday of each month (always check the Mtgs/Seminars button on this page for these and other PROTIG announced meetings). To receive email announcements of ProtIG events, join the listserv (Join the SIG button on this page) |
| Innaugural ProtIG Lecture of 2026/2027 Season September ProtIG Seminar |
| Please note the day change for the 2026-2027 seminar season. There is a change for the September seminar date and location. |
| Tuesday, September 15th, 2026 |
| 11:00 am - 12:00 pm ET |
| NIH Building 35 |
| Room 620 |
| Zhihao Zhuang, Ph.D. |
| Professor Department of Chemistry and Biochemistry University of Delaware Deward, DE |
| "Decoding the Ubiquitin Landscape Through Chemical Proteomics" |
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The ubiquitin system regulates diverse cellular processes, yet its complex regulatory networks remain challenging to define. We have developed ubiquitin-based chemical probes and proteomics strategies to investigate key components of the ubiquitin pathway, including deubiquitinating enzymes (DUBs) and ubiquitin reader proteins. In this seminar, I will discuss how integrating chemical biology with mass spectrometry-based proteomics enables the discovery, characterization, and functional analysis of ubiquitin pathway proteins. I will highlight the development of ubiquitin probes for profiling cellular DUB activities, identifying ubiquitin reader proteins, and defining molecular mechanisms underlying ubiquitin recognition and processing. These approaches provide new tools to map ubiquitin signaling networks and uncover mechanisms underlying cellular processes across diverse human diseases.
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This seminar will be videocast on
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Seminars will be webcast online and available on the
Proteomics Interest Group website http://proteome.nih.gov as an archived presentation unless otherwise noted. |
This site was updated on September 11th, 2026. Please contact Renee Olano at olanol(at)mail.nih.gov with questions or suggestions.