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| ProtIG
is an NIH Special Interest Group (SIG)
that organizes seminars and workshops in relevant areas of proteomics,
including talks on separation and protein identification methods,
determination of post-translational modifications, protein-protein
interactions, and bioinformatics and data management. A monthly seminar
series is held in the Building 50 1st floor conference room at 10am usually
on the first Friday of each month (always check the Mtgs/Seminars
button on this page for these and other PROTIG announced meetings). To
receive email announcements of ProtIG events, join the listserv (Join the SIG
button on this page)
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| ProtIG Seminar |
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| December 10, 2009 |
| 10am - 11am |
| Building 50, NIH Campus |
| 1st Floor Auditorium |
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| Suzanne Gaudet, Ph.D. |
Dana-Farber Cancer Institute, Harvard Medical School
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| "Putting numbers on the network: variability in ligand-induced cell death" |
n certain contexts, different cellular responses arise from
variations in protein expression levels or activity. Using single-
cell measurements and computational models, we recently showed how
variability in protein expression levels is responsible for cell-to-
cell variability in the timing of apoptosis in TRAIL-treated cells.
Still, predicting cellular phenotypes is challenging when multiple
proteins and complex dynamics are involved. Here I will present an
approach, based on Lyapunov analysis of differential equation models,
which allows us to compute phase diagrams mapping predicted cellular
phenotypes to different concentrations of regulatory proteins. We
validated this approach experimentally, identifying key determinants
for whether cells require, or not, mitochondrial outer membrane
permeabilization during cell death induced by TNF superfamily ligands
(Type II vs. I phenotypes).
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Seminars will be webcast online at http://videocast.nih.gov/ and available on the
Proteomics Interest Group website http://proteome.nih.gov as an archived presentation unless otherwise noted.
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| Please join us for this months Fellows Forum Seminar on the 19th of November.See the Fellows Forum for more information. |
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