NIH Proteomics Interest Group

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ProtIG is an NIH Special Interest Group (SIG) that organizes seminars and workshops in relevant areas of proteomics, including talks on separation and protein identification methods, determination of post-translational modifications, protein-protein interactions, and bioinformatics and data management. A monthly seminar series is held at 10am usually on the first Thursday of each month (always check the Mtgs/Seminars button on this page for these and other PROTIG announced meetings). To receive email announcements of ProtIG events, join the listserv (Join the SIG button on this page)

May ProtIG Seminar
May 6th, 2016
9:00am - 10:00pm
Building 50, NIH Campus
Room 1227/1233 (Front Lobby)
Dave Pagliarini, Ph.D.
Investigator and Director of Metabolism, Morgridge Institute for Research
Associate Professor of Biochemistry, University of Wisconsin-Madison

"Using proteomics to elucidate mitochondrial protein function."

Mitochondrial dysfunction is associated with a spectrum of rare inborn errors of metabolism and an increasing number of common diseases, including Parkinson’s, Alzheimer’s, various cancers and type 2 diabetes. However, the nature and cause of this dysfunction is quite often confounding or unclear. Central to this problem is the recent realization that mitochondria are much more complex than once thought and possess hundreds of proteins with no known biochemical functions. Elucidating the biochemical functions of these proteins has become a major bottleneck in understanding basic mitochondrial biology and the pathophysiology of mitochondria-related disorders. The long-term significance of my research program is to widen this biomedical bottleneck by accelerating the functional annotation of key disease-related “orphan” mitochondrial proteins (OMPs), thereby taking an important first step toward rational therapeutic design for many mitochondrial diseases. We do so by first designing large- scale mass spectrometry and computational analyses designed to make initial connections between OMPs and known mitochondrial pathways and processes, and then employing mechanistic and structural approaches to define the functions of select OMPs at biochemical depth.

The lecture will be transmitted by GoTo Meeting

You can also dial in using your phone. United States +1 (408) 650-3123

Access Code: 220-532-805

Please mute your microphone unless you are asking a question.

Seminars will be webcast online at and available on the
Proteomics Interest Group website as an archived presentation unless otherwise noted.

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This site was updated on May 5th, 2016. Please contact Renee Olano at olanol(at) with questions or suggestions.