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| ProtIG
is an NIH Special Interest Group (SIG)
that organizes seminars and workshops in relevant areas of proteomics,
including talks on separation and protein identification methods,
determination of post-translational modifications, protein-protein
interactions, and bioinformatics and data management. A monthly seminar
series is held in the Building 50 1st floor conference room at 10am usually
on the first Thursday of each month (always check the Mtgs/Seminars
button on this page for these and other PROTIG announced meetings). To
receive email announcements of ProtIG events, join the listserv (Join the SIG
button on this page)
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Please notice the location and time change. Due to this alternate location this seminar will not be available for videocast. |
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| May ProtIG Seminar |
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| May 2nd, 2013 |
| 11:00am - 12:00pm |
| Building 50, NIH Campus |
| Conference room 1227/1233 |
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| Austin Yang, Ph.D. |
University of Maryland
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| "ESCRT-III complex assembly and its role in exosome biogenesis and biomarker discovery" |
The goal of this study is to use a proteomic approach
to understand the roles of the ESCRTIII-VPS4 complex in the formation of
multiple vesicular body (MVB)-dependent exosomes. Results from our study suggest that attenuation of the expression of VPS4, an AAA+ ATPase, can alter the content of exosomes that are secreted by breast cancer cells and render them resistant to chemotoxins. Mostly importantly, we have also found that this aberrant VPS4-mediated MVB dysfunction is often associated with high grade and recurrent tumors. We will discuss the pathological consequences of this VPS4-mediated alternative exosome secretion and its potential impact on biomarker discovery.
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| Please remember everyone is welcome to join us for the Fellows Forum Seminar on the 15th of May (in NEW room 4N-230) where Virginie Sjoelund, PhD [NIAID] will present. See the Fellows Forum for more information. |
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