NIH Proteomics Interest Group

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ProtIG is an NIH Special Interest Group (SIG) that organizes seminars and workshops in relevant areas of proteomics, including talks on separation and protein identification methods, determination of post-translational modifications, protein-protein interactions, and bioinformatics and data management. A monthly seminar series is held in the Building 50 1st floor conference room at 10am usually on the first Friday of each month (always check the Mtgs/Seminars button on this page for these and other PROTIG announced meetings). To receive email announcements of ProtIG events, join the listserv (Join the SIG button on this page)
ProtIG Seminar
November 6, 2009
10am - 11am
Building 50, NIH Campus
1st Floor Auditorium
William Noble, Ph.D.
Department of Genome Sciences
University of Washington


"Machine learning methods for identifying peptides and proteins from shotgun proteomics data"

Shotgun proteomics coupled with database search software allows the identification of a large number of peptides or proteins from a single biological sample. In this talk, I will describe a series of computational methods that use machine learning techniques to improve our ability to map observed fragmentation spectra to peptides and proteins. These methods combine prior knowledge about peptide fragmentation and mass spectrometry with observed properties of a collection of related spectra, thereby identifying larger sets of peptides and proteins at low false discovery rates.


ProtIG Special Seminar
November 18, 2009
10am - 11am
Building 50, NIH Campus
1st Floor Auditorium
Chris Turck, Ph.D.
Max Planck Institute of Psychiatry, Proteomics and Biomarkers, Munich

"The quest for psychiatric disorder biomarkers: from protein expression to isoforms to pathways"

Biomarkers, which are measures of biological parameters of disease that also can predict which new molecular entities will be effective and safe in treating patients, are experiencing a great deal of attention in today’s life sciences. For both types of investigation, drug response and disease susceptibility, biomarkers are needed in order to move the area of psychiatric disorders into the rest of medicine. Ultimately, it is hoped that biomarkers will assist in stratifying patient groups with similar clinical features for a personalized medicine approach and at the same time help in the identification of neural circuitries that are responsible for disease etiology. This will enable the complementation of the presently applied DSM-IV and ICD-10 criteria with specific sets of biomarkers and result in a more precise nosological framework for psychiatric disorders.

Good animal models representing distinct features of a psychiatric disorder phenotype are one way to come up with specific biomarkers. Here a good representation of the relevant psychiatric disease mechanisms in an animal disease model is critical in order to enable subsequent pre-clinical to clinical study translation. The identified biomarker candidates can also provide important information on pathways that are relevant for psychiatric disorder pathophysiology. We have implemented a comprehensive and sensitive platform that is based on metabolic labeling of mouse models with stable isotopes and subsequent mass spectrometry-based quantitation. Proteomic and metabolomic analyses are implicating pathways relevant for disease pathobiology.


Seminars will be webcast online at http://videocast.nih.gov/ and available on the
Proteomics Interest Group website http://proteome.nih.gov as an archived presentation unless otherwise noted.


Please join us for this months Fellows Forum Seminar on the 19th of November.See the Fellows Forum for more information.

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This site was updated on November 19, 2009. Please contact Renee Olano at olanol(at)mail.nih.gov with questions or suggestions.