NIH Proteomics Interest Group

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The Next Step: Exploring the Proteome

A one-day tutorial for NIH scientists and decision makers on the emerging field of proteomics.

A digital archive of the May 21 Symposium is now accessible using RealPlayer. Each lecture slide can be viewed and searched at your command with the speakers' voices synchronized to the slides.
Click here to see it!

Symposium Information:

  • Schedule of Speakers
  • Sponsors /
    Organizing Committee
  • ProtIG home page
  • Other proteome links:

  • NIH Mass Spectrometry Interest Group
  • Proteome Software on the Internet
  • Sources of Proteome Information
  • PROTEOME  =  PROTEins expressed by the genOME

    *The genome of a muticellular organism is constant.  In general, somatic cells contain identical DNA copies.

    *Proteomes vary with cell type. Proteins present in one cell type (for example, hepatocyte) differ from those of another cell type in the same organism (neuron, fibroblast) although all have the same genome.

    *Proteomes vary with cell history and are time dependent. Proteins present in a newly divided cell differ from those in an older or stressed or drug-treated cell. 

    *Proteomes reflect a wide dynamic range of individual protein concentrations. Some proteins are expressed in thousands of copies per cell (structural or housekeeping proteins) and others are expressed transiently as a few copies per cell to control or signal cell events.

    *Proteomes reflect active cellular species.  Eucaryotic proteins are post-translationally modified. 

    Proteome research brings together protein and analytical chemists, geneticists, molecular biologists and bioinformatics specialists to capitalize on the availability of human gene sequences and emerging techniques for the analyses of complex mixtures of proteins.  Symposium speakers will present varying perspectives on their proteome-based research from clinical medicine to bioinformatics via application of emerging technologies in protein chips, electrophoresis and mass spectrometry.


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    This site was developed by Lewis Pannell. Please contact him by email at with any problems or suggestions. Thanks!