|
|
|
|
| Institute: |
Lab or Branch |
| Agilent Technologies, Santa Clara, CA |
|
|
| Title: |
| A New Software Environment for Comprehensive
Review of MS Data from Proteomics Experiments |
|
| Authors: |
| C.A. Miller, B.D. Miller, J. Roark |
|
| Abstract: |
| Mass spectrometry has become a core technology
for proteomics research and the increasing interest in
large-scale proteome characterization, e.g. shotgun proteomics,
can readily lead to a bottleneck in data interpretation
and review. An advanced informatics tool is introduced
which provides an environment for the rapid, comprehensive
review of data from large-scale proteomics experiments.
Within this environment, protein database search, result
review and validation of database search results can be
performed. In addition, large datasets can be compared
across multiple experiments and the results can be readily
summarized at the protein level. For those peptides not
identified through database search, an automated de novo
sequencing tool is available and the results from this
tool are integrated into the informatics environment to
enable cross correlation with database search results.
The software also offers an open platform for analysis
of data from multiple MS techniques and vendors. This
work will demonstrate the features and performance of
the new informatics software for analyzing data from typical
proteomics experiments. |
|
| |
|
